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By Amar Chatterjee

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Subclinical depletion of primordial follicular reserve in mice treated with cyclophosphamide: clinical importance and proposed accurate investigative tool, Hum Reprod 14: 1903–07. , Howell, A. & Rubens, R. (1986). Mechanism of action of adjuvant chemotherapy in early breast cancer, Lancet 2: 411–414. , Price, K. & Senn, H. (1998). Prognostic impact of amenorrhea after adjuvant chemotherapy in premenopausal breast cancer patients with axillary node involvement: results of the international breast cancer study group (IBCSG) trial VI, Eur J Cancer 34(5): 632–640.

1995). The loss of bone mass occurs with anorexia nervosa, hypothalamic amenorrhea and in ovarian deficiencies. , 2000). , 1991). Decreased pulse amplitude and frequency in the early follicular phase cause a failure of folliculogenesis and the resulting deficiency of ovarian steroids subsequently leads to loss of the bone mass (Warren, 2011). Estrogen deficiency was proposed as the main factor contributing to low BMD in anorexia nervosa. , 1994). The BMD at the lumbar spine determined by various methods is reduced in adolescent girls with amenorrhea, as compared with those who have regular cycles.

Price, K. & Senn, H. (1998). Prognostic impact of amenorrhea after adjuvant chemotherapy in premenopausal breast cancer patients with axillary node involvement: results of the international breast cancer study group (IBCSG) trial VI, Eur J Cancer 34(5): 632–640. , Devalas, G. & Diamanti-Kandarakis, E. (2010). The impact of oral contraceptives and metformine on Anti-müllerian hormone serum levels in women with polycystic ovari syndrome and biochemical hyperandrogenemia, Gynecol Endocrinol p. 14.

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